Table 2.
Relationship Between Combination of PON1 rs854560 (LM + MM) and ApoE ∊4 Genotypes and the Outcome of Having AD and VaD.a
| rs854560 (LM+MM) | ApoE ∊4 | AD (n = 75) | VaD (n = 46) | HC (n = 120) | OR (95%CI) | P value |
|---|---|---|---|---|---|---|
| Absent | Absent | 27 (36.0%) | 24 (52.2%) | 64 (53.4%) | 1 (reference) | - |
| Absent | Present | 23 (30.7%) | 7 (15.2%) | 12 (10.0%) | 4.5 (1.9-10.4)b 1.5 (0.5-4.4)c | <.001b .4c |
| Present | Absent | 13 (17.3%) | 8 (17.4%) | 40 (33.3%) | 0.7 (0.3-1.6)b 0.5 (0.2-1.3)c | 0.5b 0.1c |
| Present | Present | 12 (16.0%) | 7 (15.2%) | 4 (3.3%) | 7.1 (2.1-24.0)b 4.6 (1.2-17.3)c | 0.002b 0.02c |
Abbreviations: AD, Alzheimer’s disease; VaD, vascular dementia; HC, healthy control; CI, confidence interval; OR, odds ratio; PON1, paraoxonase 1; ApoE, apolipoprotein E.
a Odds Ratio of having AD and VaD against HC.
b P values and OR of AD versus HC.
c P values and OR of VaD versus HC.