Table 1.
Standardized Mean Differences in Mg Parameters in Patients With AD Versus Healthy and Medical Controls (Cross-Sectional Studies).
| Parameter | Studies, N | AD Group, N | Control Group, N | SMD (95% CI) | P Value | Heterogeneity |
|---|---|---|---|---|---|---|
| Healthy Controls | ||||||
| Serum Mg | 4 | 190 | 189 | −0.07 (−0.98 to 0.85) | 0.89 | Tau2 = 0.79; χ2 = 45.12, df = 3 (P < .0001); I2 = 93% |
| Plasma Mg | 3 | 56 | 68 | −0.19 (−0.58 to 0.20) | 0.34 | Tau2 = 0.02; χ2 = 2.33, df = 2 (P = .31); I2 = 31% |
| CSF Mg | 2 | 171 | 56 | −0.35 (−0.65 to −0.04) | 0.02 | Tau2 = 0.00; χ2 = 0.05, df = 1 (P = .82); I2 = 0% |
| Ionized/blood cells Mg | 2 | 59 | 64 | −0.02 (−0.72 to 0.68) | 0.98 | Tau2 = 0.18; χ2 = 3.50, df = 1 (P = .06); I2 = 71% |
| Hair Mg | 2 | 44 | 80 | −0.75 (−1.13 to −0.36) | 0.0001 | Tau2 = 0.00; χ2 = 0.56, df = 1 (P = .46); I2 = 0% |
| Medical Controls | ||||||
| Serum Mg | 2 | 73 | 99 | −0.21 (−0.52 to 0.10) | 0.18 | Tau2 = 0.00; χ2 = 0.05, df = 1 (P = .82); I2 = 0% |
| Plasma Mg | 1 | 12 | 12 | −1.54 (−2.47 to −0.61) | 0.001 | Not applicable |
| CSF Mg | 1 | 21 | 15 | 0.42 (−0.25 to 1.09) | 0.22 | Not applicable |
| Ionized/blood cells Mg | 1 | 36 | 65 | −0.40 (−0.82 to 0.00) | 0.05 | Not applicable |
| Hair Mg | No studies available | |||||
Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; CSF, cerebrospinal fluid; Mg, magnesium; SMD, standardized mean differences.