Table 1.
Characteristics of the C282Y Polymorphism in the HFE Gene Genotype Distributions in Studies Included in This Meta-Analysis.
| Author | Year | Country | Ethnicity | Number (Case/Control) | Genotype CC/CY/YY | P for HWE in control | P for HWE in case | References | |
|---|---|---|---|---|---|---|---|---|---|
| Case | Control | ||||||||
| Borie et al14 | 2002 | Paris | Europe | 71/57 | 66/5/0 | 52/5/0 | .73 | .76 | 14 |
| Buchanan et al21 | 2002 | Australia | Oceania | 438/485 | 391/46/1 | 405/76/4 | .84 | .77 | 21 |
| Dekker et al16 | 2003 | Netherlands | Europe | 101/2136 | 89/10/2 | 1838/290/8 | .34 | .06 | 16 |
| Dekker et al16 | 2003 | Netherlands | Europe | 44/2136 | 38/6/0 | 1838/290/8 | .34 | .63 | 16 |
| Guerreiro et al18 | 2006 | Portugal | Europe | 132/115 | 114/18/0 | 110/5/0 | .81 | .40 | 18 |
| Aamodt et al15 | 2007 | Norway | Europe | 315/396 | 263/50/2 | 330/64/2 | .56 | .82 | 15 |
| Halling et al20 | 2008 | Denmark | Europe | 54/110 | 44/10/0 | 87/21/2 | .58 | .45 | 20 |
| Greco et al17 | 2011 | Italy | Europe | 181/180 | 178/3/0 | 177/3/0 | .91 | .91 | 17 |
| Mariani et al19 | 2013 | Italy | Europe | 73/139 | 70/3/0 | 137/2/0 | .93 | .93 | 19 |
Abbreviations: HFE, hemochromatosis; HWE, Hardy-Weinberg equilibrium.