. 2015 Sep 3;31(3):201–207. doi: 10.1177/1533317515602220

Table 3.

Pooled Measures on the Relationship of C282Y and H63D polymorphisms in the HFE Gene With Risk of Parkinson’s Disease.^a,b,c

Polymorphism		Inherited Model	All Included Articles		Q Value	I² (%)	P for Heterogeneity	After Excluding Articles With OR > 3.0		I² (%)	P for Heterogeneity	Articles Excluded
			Pooled OR (95% CI)					Pooled OR (95% CI)
			FEM	REM				FEM	REM
All data	C282Y	Dominant	0.87 (0.70-1.09)	0.95 (0.69-1.30)	12.56	36.3	.13	0.82 (0.65-1.02)	0.82 (0.65-1.02)	0.0	.63	¹⁸
		Recessive^d	1.58 (0.61-4.10)	1.40 (0.43-4.58)	11.56	30.8	.22	0.77 (0.23-2.56)	0.77 (0.23-2.56)	0.0	.56	^14,16-19
		Codominant	0.88 (0.72-1.09)	0.95 (0.71-1.29)	12.74	37.2	.12	0.83 (0.67-1.03)	0.83 (0.67-1.03)	0.0	.55	¹⁸
	H63D	Dominant	1.04 (0.87-1.24)	1.04 (0.87-1.24)	7.00	0.0	.60	–	–	–	–	–
		Recessive	1.23 (0.70-2.18)	1.23 (0.70-2.18)	7.00	0.0	.78	–	–	–	–	–
		Codominant	1.04 (0.89-1.22)	1.04 (0.89-1.22)	7.00	0.0	.58	–	–	–	–	–
Europe	C282Y	Dominant	1.04 (0.80-1.36)	1.05 (0.79-1.41)	8.64	7.4	.37	0.95 (0.72-1.26)	0.95 (0.72-1.3)	0.0	.93	¹⁸
		Recessive^d	2.37 (0.83-6.82)	2.37 (0.83-6.82)	8.00	0.0	.43	1.19 (0.29-5.00)	1.19 (0.29-5.0)	0.0	.66	¹⁶
		Codominant	1.05 (0.82-1.35)	1.05 (0.82-1.36)	8.07	0.9	.42	0.97 (0.75-1.26)	0.97 (0.75-1.3)	0.0	.94	¹⁸

Abbreviations: CI, confidence interval; FEM, fixed-effect model; HFE, hemochromatosis; OR, odds ratio; REM, random-effect model.

^aDominant model: YY + CY versus CC for C282Y and DD + HD versus HH for H63D.

^bRecessive model: YY versus CY + CC for C282Y and DD versus HD + HH for H63D.

^cCodominant model: Y versus C for C282Y and for D versus H for H63D.

^dFour articles (Borie et al, Guerreiro et al, Greco et al, and Mariani et al) in C282Y were not sufficient to calculated pooled OR.