Table 1.
IC50 values (μM) as inferred from 72 h MTT assays of Pt prodrugs and relevant compounds tested against cancer cell lines. 2MSA-2: MSA-2 is present at two times the equimolar amount of CDDP.
| Compounds | HK-2 | Caov3 | PANC-1 | BxPC3 | Pan02 |
|---|---|---|---|---|---|
| I | 0.12 ± 0.01 | 0.7 ± 0.1 | 0.06 ± 0.02 | 0.02 ± 0.01 | 0.05 ± 0.01 |
| II | 3.6 ± 1.2 | 5.3 ± 0.4 | 6.9 ± 0.9 | 4.9 ± 0.8 | 8.4 ± 0.7 |
| CDDP | 8.2 ± 0.5 | 26.8 ± 2.2 | 11.1 ± 1.3 | 1.6 ± 0.1 | 8.3 ± 0.6 |
| CDDP + MSA-2 | 9.9 ± 1.3 | 31.8 ± 1.3 | 11.0 ± 1.6 | 1.5 ± 0.1 | 10.0 ± 0.4 |
| CDDP + 2MSA-2 | 11.4 ± 1.5 | 31.5 ± 1.1 | 11.3 ± 1.1 | 1.5 ± 0.1 | 10.9 ± 0.8 |
| Oxoplatin | 38.7 ± 4.1 | >50 | >50 | >50 | >50 |
| MSA-2 | > 50 | >50 | >50 | >50 | >50 |