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. Author manuscript; available in PMC: 2024 Feb 8.
Published in final edited form as: J Med Chem. 2023 Jul 18;66(14):9992–10009. doi: 10.1021/acs.jmedchem.3c00908

Table 3.

Effects of Representative 5-HT2CR PAMs and Dual 5-HT2CR/5-HT2AR PAMs (1 nM) on 5-HT-Induced Cai2+ Release in h5-HT2BR-CHO Cellsb

Compound PH Emax RFU (%5-HT)a
8 graphic file with name nihms-1963857-t0036.jpg 95.6 ± 4.6
9 graphic file with name nihms-1963857-t0037.jpg 106.1 ± 7.5
11 graphic file with name nihms-1963857-t0038.jpg 97.2 ± 9.2
12 graphic file with name nihms-1963857-t0039.jpg 92.4 ± 3.2
13 graphic file with name nihms-1963857-t0040.jpg 98.4 ± 4.6
25 graphic file with name nihms-1963857-t0041.jpg 100.6 ± 4.4
a

Addition of the synthetic compound (1 nM) occurred 15 min prior to assessment of Cai2+ release evoked by increasing concentrations of 5-HT (vehicle, 10−11 to 10−5 M) in h5-HT2BR-CHO cells. Data are presented as maximal 5-HT-induced Cai2+ release (Emax).

b

p < 0.05. Comparisons between means for Emax were conducted with an unpaired t test with Welch’s correction (GraphPad Prism). All statistical analyses were conducted with an experiment-wise error rate of α = 0.05.