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In Vitro PK Data for Compound 13
| MDCK-MDR1 permeability | without P-gp inhibitor: PappA → B = 5.86 × 10−6 cm/s; PappB → A = 3.23 × 10−6 cm/s; efflux ratio: 0.6 |
| with P-gp inhibitor:PappA → B = 10.64 × 10−6 cm/s; PappB → A = 4.77 × 10−6 cm/s; efflux ratio: 0.4 | |
| kinetic solubility (PBS pH = 7.2) | 48.55 μg/mL |
| liver microsomal clearance | CLr = 174.66 μL/min/mg |
| CLh = 148.85 μL/min/mg |
