Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 8;223(4):e202308023. doi: 10.1083/jcb.202308023

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Beaumale et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — p80 structural alignment and Katanin•MT interacting model. (A) Structural model of MEI-2 obtained using AlphaFold2 prediction website. The carbon backbone is represented using cartoon mode (in green), and the surface color shows the electrostatic potential calculated using chimera electrostatic potential Coulombic function. * corresponds to the locations of KK pair residues identified in this study. (B) Protein sequences alignment of p80 and p80-like Katanin subunits from different species. CE: C. elegans; HS: H. sapiens; MM: M. musculus; AT: A. thaliana; DM: D. melanogaster. (C) Structural alignment of the C-terminal part of p80 and p80-like Katanin subunits from different species. Except for MM KATNB1, which is the X-ray structure obtained in complex with p60 fragment (PDB: 5LB7) (Jiang et al., 2017), structures shown are alpha-fold prediction aligned on MEI-2 structural prediction. The region shown is limited to the “structured region” of MEI-2 (aa 105–280). Single-protein structures are presented in Fig. S4. (D) Working model of microtubule binding of Katanin essential for microtubule severing activity.