TABLE 1.
Cytokine mRNA levels in the lungs of four strains of inbred mice 14 days after infection with C. immitisa
| Cytokine | Valueb for mouse
strain:
|
|||
|---|---|---|---|---|
| D2 | B6 | BALB/c | CAST/Ei | |
| IL-10 | 5.2 × 103 | 4.2 × 105 | 1.1 × 105 | 1.9 × 105 |
| IL-4 | 1.7 × 104 | 6.2 × 104 | 3.5 × 105 | 9.0 × 104 |
| IL-6 | 1.6 × 105 | 3.2 × 105 | NDc | ND |
| IL-2 | 5.0 × 103 | 4.0 × 104 | ND | ND |
| IL-12 p40 | 6.0 × 104 | 1.4 × 104 | 5 × 104 | 6.2 × 104 |
| IFN-γ | 1.7 × 105 | 1.1 × 105 | 9.0 × 105 | 8.5 × 105 |
| TNF-α | 1.5 × 105 | 1.0 × 106 | 5.6 × 105 | 6.4 × 105 |
CFU in lungs were as follows: D2, 8.6 × 103; B6, 2 × 106; BALB/c, 8.1 × 105, CAST/Ei, >2 × 106. Values are geometric means for surviving mice; there were 10 mice in each group initially.
Number of mRNA molecules per microgram of RNA from four mice.
ND, not determined.