Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 2;32(2):155–162. doi: 10.1038/s41431-022-01180-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), under exclusive licence to European Society of Human Genetics 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

PMC Copyright notice

Fig. 2 — Rectangles with continous borders represent substances in the folic acid cycle; rectangles with dotted borders represent substances in the methionine cycle; rectangles with dashed borders represent substances needed for DNA synthesis; ovals with continous borders represent enzymes; ovals with dashed borders represent cofactors; lines originating from methotrexate represent enzyme inhibition by methotrexate; B12 vitamin B12; DHFR dihydrofolate reductase; MS methionine synthase; SHMT serine hydroxymethyltransferase; TS thymidylate synthase.