Table 6.

Differentially expressed pathways in macrophage subsets.

CL	pathway	NES
0	REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE	3.48
0	WP_CYTOPLASMIC_RIBOSOMAL_PROTEINS	3.08
0	CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN	2.99
0	MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN	2.97
0	TABULA_MURIS_SENIS_MARROW_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_CELL_AGEING	2.96
0	GOCC_CYTOSOLIC_RIBOSOME	2.91
0	REACTOME_NONSENSE_MEDIATED_DECAY_NMD_INDEPENDENT_OF_THE_EXON_JUNCTION_COMPLEX_EJC	2.85
0	TABULA_MURIS_SENIS_MARROW_GRANULOCYTE_AGEING	2.85
0	TABULA_MURIS_SENIS_MARROW_GRANULOCYTOPOIETIC_CELL_AGEING	2.79
0	INGRAM_SHH_TARGETS_DN	2.75
0	GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME	2.73
0	GOCC_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT	2.71
0	HALLMARK_KRAS_SIGNALING_UP	2.69
0	BREDEMEYER_RAG_SIGNALING_NOT_VIA_ATM_DN	2.4
0	TABULA_MURIS_SENIS_MARROW_ERYTHROBLAST_AGEING	2.37
0	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	2.37
0	HARRIS_BRAIN_CANCER_PROGENITORS	2.35
0	REACTOME_TRIGLYCERIDE_METABOLISM	2.16
0	GOCC_CHYLOMICRON	2.1
0	BOYLAN_MULTIPLE_MYELOMA_C_D_DN	2.09
1	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	2.5
1	GOMF_CYTOKINE_ACTIVITY	2.5
1	HALLMARK_COAGULATION	2.5
1	MIR_5101	2.47
1	GOMF_HEPARIN_BINDING	2.44
1	GOBP_CELL_ADHESION_MEDIATED_BY_INTEGRIN	2.4
1	GOMF_CARGO_RECEPTOR_ACTIVITY	2.39
1	GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX	2.38
1	GOMF_OPSONIN_BINDING	2.38
1	GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE	2.35
1	GOMF_COMPLEMENT_BINDING	2.35
1	GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS	2.35
1	GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING	2.3
1	REACTOME_ELASTIC_FIBRE_FORMATION	2.3
1	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	2.3
1	LEE_BMP2_TARGETS_UP	2.29
1	CUI_TCF21_TARGETS_2_DN	2.29
1	AFFAR_YY1_TARGETS_UP	2.27
1	GOBP_INTEGRIN_ACTIVATION	2.26
1	GOBP_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	2.25
2	TABULA_MURIS_SENIS_LIMB_MUSCLE_MACROPHAGE_AGEING	3.02
2	GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION	2.96
2	ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP	2.91
2	GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_CELL_CELL_ADHESION	2.9
2	QI_PLASMACYTOMA_UP	2.88
2	WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP	2.88
2	DESCARTES_ORGANOGENESIS_WHITE_BLOOD_CELLS	2.83
2	REACTOME_RHO_GTPASE_EFFECTORS	2.83
2	GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION	2.82
2	TABULA_MURIS_SENIS_SPLEEN_CD8_POSITIVE_ALPHA_BETA_T_CELL_AGEING	2.81
2	TABULA_MURIS_SENIS_SPLEEN_T_CELL_AGEING	2.81
2	LIAN_LIPA_TARGETS_6M	2.79
2	GOBP_LEUKOCYTE_CELL_CELL_ADHESION	2.78
2	LIAN_LIPA_TARGETS_3M	2.78
2	YU_MYC_TARGETS_DN	2.78
2	TABULA_MURIS_SENIS_LIVER_MYELOID_LEUKOCYTE_AGEING	2.77
2	TABULA_MURIS_SENIS_MARROW_HEMATOPOIETIC_PRECURSOR_CELL_AGEING	2.76
2	GOBP_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN	2.76
2	GOBP_POSITIVE_REGULATION_OF_CELL_ACTIVATION	2.75
2	TABULA_MURIS_SENIS_MARROW_MONOCYTE_AGEING	2.72
3	HALLMARK_E2F_TARGETS	3.08
3	BURTON_ADIPOGENESIS_3	2.98
3	LAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_LARGE_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP	2.97
3	HALLMARK_MYC_TARGETS_V1	2.96
3	MARKEY_RB1_ACUTE_LOF_UP	2.93
3	MORI_IMMATURE_B_LYMPHOCYTE_DN	2.9
3	LAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_SMALL_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP	2.88
3	MORI_LARGE_PRE_BII_LYMPHOCYTE_UP	2.87
3	BERENJENO_TRANSFORMED_BY_RHOA_UP	2.82
3	MORI_PRE_BI_LYMPHOCYTE_UP	2.8
3	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	2.79
3	HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP	2.79
3	HALLMARK_G2M_CHECKPOINT	2.73
3	KAMMINGA_EZH2_TARGETS	2.73
3	KONG_E2F3_TARGETS	2.72
3	ISHIDA_E2F_TARGETS	2.72
3	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	2.71
3	GOBP_DNA_REPLICATION	2.71
3	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	2.7
3	GOBP_DNA_TEMPLATED_DNA_REPLICATION	2.7

CL, cluster; NES, normalized enrichment score.