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Pathological changes in various organs of tree shrews. Subcutaneous injection of BLM successfully induced a tree shrew SSc model to mimic human SSc inflammation and fibrosis characteristics. Representative skin, lung, esophagus and kidney histologic sections in each group of tree shrews stained with hematoxylin and eosin (HE) and Masson’s trichrome (original magnification ×200 for skin, lung and kidney; original magnification ×100 for esophagus) are shown.
