Table 1.
Skin and lung pathology scores of tree shrews in each group.
| Groups | n | Skin thickness (μm) |
Skin inflammation score |
Skin CVF (%) |
Skin HYP content (mg/g) |
Lung inflammation score |
Lung fibrosis Ashcroft |
Lung HYP content (mg/g) |
|---|---|---|---|---|---|---|---|---|
| Control | 6 | 134.87±19.97 | 0.40±0.13 | 32.45±8.37 | 0.60±0.18 | 0.38±0.14 | 3.87±0.50 | 0.84±0.22 |
| Low-dose BLM | 7 | 152.94±14.37 | 0.49±0.16 | 36.92±4.05 | 0.97±0.31* | 0.69±0.28 | 4.27±0.40 | 0.85±0.07 |
| Medium-dose BLM | 7 | 230.05±44.42**# | 2.23±0.84**## | 43.69±8.70* | 1.21±0.22** | 1.51±0.34***### | 4.88±0.85** | 0.82±0.13 |
| High-dose BLM | 9 | 236.21±57.02**## | 1.49±0.35***### | 50.29±7.45***## | 1.29±0.35***# | 0.91±0.32**&&& | 4.55±0.52* | 0.80±0.11 |
| F | 11.750 | 24.06 | 8.449 | 8.122 | 18.449 | 3.394 | 0.185 | |
| P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.033 | 0.906 |
Inflammation and fibrosis scores were significantly higher in the skin and lungs of the tree shrew SSc model. Data are shown as the mean ± SD. (1) *P<0.05, **P<0.01, ***P<0.001 compared with control group; (2) #P<0.05, ##P<0.01, ###P<0.001 compared with Low-dose BLM group; (3) &P<0.05, &&P<0.01, &&&P<0.001 compared with Medium-dose BLM group.