Table 2.
Significantly differentially abundant urinary cytokines between the never and relapse groups.
| IL-1β | MCP-1 | IL-8 | IL-18 | IL-13 | IL-4 | ||
|---|---|---|---|---|---|---|---|
| Raw (pg/ml) | Never | 1.5 (1.5–3.2) | 35.13 (1.9–167.4) | 7.6 (2–12.7) | 22.14 (12.4–52.5) | 1.4 (1.4–7.68) | 1 |
| Relapse | 35.57 (7.6–152.8) | 271.6 (72.1–519) | 825.4 (130.9–1789) | 106 (69.79–319.2) | 1.4 | 1 | |
| P-value | <0.000001 | 0.000425 | <0.000001 | 0.000001 | 0.03134 | 0.227390 | |
| Fold-change | 23.4 | 7.73 | 108.6 | 4.78 | 1 | 1 | |
| Normalized (pg/μg) | IL-1β/Cr | MCP-1/Cr | IL-8/Cr | IL-18/Cr | IL-13/Cr | IL-4/Cr | |
| Never | 0.003 (0.001–0.01) | 0.065 (0.007–0.18) | 0.012 (0.006–0.04) | 0.0476 (0.029–0.104) | 0.0052 (0.002–0.008) | 0.00281 (0.001–0.005) | |
| Relapse | 0.058 (0.01–0.22) | 0.389 (0.21–0.49) | 0.940 (0.17–2.56) | 0.157 (0.093–0.376) | 0.0021 (0.001–0.004) | 0.00129 (0.0009–0.002) | |
| P-value | 0.000050 | 0.000078 | <0.000001 | 0.000017 | 0.002867 | 0.038516 | |
| Fold-change | 19.3 | 5.98 | 78.3 | 3.29 | 0.4 | 0.46 |
Raw and normalized median and interquartile range for each significant cytokine. P-values generated by the Mann–Whitney U test. Fold-change was calculated as a ratio of the median cytokine concentration in the relapse group and the median value in the never group.