Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 26;15:1347683. doi: 10.3389/fimmu.2024.1347683

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Yang, Li, Zhu, Wang, Zhang, Zhao, Zhang, Zhu, Xu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cell communication network reveals significant role of high PAK2 expression cancer cells in liver metastasis. (A, B) Cell communication networks in pancreatic cancer primary and liver metastasis show significant differences in signaling communication. (C, D) Pancreatic cancer cells exhibit similar outgoing communication in primary and liver metastasis, while the incoming communication shows a larger difference in liver metastasis. (E, F) Interaction quantity and interaction weight/strength of various cells in the pancreatic cancer tumor microenvironment (TME) in the communication network. (G, H) Contribution of various cells in the pancreatic cancer TME as signal senders and receivers to various signaling pathways. (I-L) Specific analysis results of the EGF signaling pathway. (I) Sine wave graph of cell communication in the EGF signaling pathway. (J, K) Contribution heatmap of each cell communication in the EGF signaling pathway. (L) Receptor with the most frequent communication in the EGF signaling network. (M-Q) Contribution heatmap of cell communication in various signaling pathways, including GDF, OCLN, WNT, CD46, and CDH.