hdWGCNA	high-dimensional weighted gene co-expression network analysis
LRG	liver metastasis-related gene
GEO	Gene Expression Omnibus
TCGA	The Cancer Genome Atlas
PCA	principal component analysis
UMAP	Uniform Manifold Approximation and Projection
LASSO	Least Absolute Shrinkage and Selection Operator
SVM-RFE	Support Vector Machine Recursive Feature Elimination
SVM	support vector machines
RF	Random Forest
ROC	Receiver Operating Characteristic
GSVA	Gene Set Variation Analysis
KEGG	Kyoto Encyclopedia of Genes and Genomes
PPI	protein-protein interaction
TF	transcription factor
IC50	half-maximal inhibitory concentration
WGCNA	Weighted Gene Co-expression Network Analysis
AUC	area under the curve
ssGSEA	Single-Sample Gene Set Enrichment Analysis
CopyKAT	Copy Number Karyotyping of Aneuploid Tumors
NK	natural killer cells
PMN	Polymorphonuclear neutrophils
ICAM-1	intercellular adhesion molecule-1
TME	tumor microenvironment
VEGF	vascular endothelial growth factor
Treg	regulatory T cells
MDSC	myeloid-derived suppressor cells
PAK	P21-activated kinase
PAK2	P21-activated kinase 2
CEACAM	carcinoembryonic antigen-related cell adhesion molecule
HSPGs	Heparan sulfate proteoglycans
HS	heparan sulfate
GAG	glycosaminoglycan
ECM	extracellular matrix
EGF	Epidermal Growth Factor
EGFR	Epidermal Growth Factor Receptor
NCOA	Nuclear Receptor Coactivator
ER	estrogen receptor
AR	androgen receptor