TABLE 2.
Comparisons of AKI clinical course between patients with AKI stages 1A and 1B
| Stage 1A N = 2,064 | Stage 1B N = 2,590 | p | |
|---|---|---|---|
| Peak creatinine, median (IQR) mg/dL | 1.24 (1.00, 1.49) | 2.76 (1.94, 4.70) | < 0.001 |
| Delta creatinine (peak minus baseline), median (IQR) mg/dL | 0.43 (0.30, 0.61) | 0.80 (0.50, 1.45) | < 0.001 |
| Progression of AKI, n (%) | 453 (21.9) | 1,041 (40.2) | < 0.001 |
| Peak AKI stage, n (%) | |||
| 2 | 257 (12.4) | 191 (7.4) | < 0.001 |
| 3 | 196 (9.5) | 850 (32.8) | — |
| AKI recovery, n (%) | |||
| None | 265 (10.2) | 693 (26.8) | < 0.001 |
| Partial | 6 (2.9) | 114 (4.3) | — |
| Complete | 1,793 (86.9) | 1,783 (68.9) | — |
| Albumin usea, n (%) | 399 (19.3) | 655 (25.3) | < 0.001 |
| Crystalloid useb, n (%) | 1,258 (60.9) | 1,485 (57.3) | 0.01 |
| Midodrine and octreotide combination use, n (%) | 50 (2.4) | 117 (4.5) | < 0.001 |
| Hemodialysis use, n (%) | 4 (< 0.01) | 233 (9.0) | < 0.001 |
| ICU admission/transfer, n (%) | 500 (24.2) | 601 (23.2) | 0.44 |
| ACLF, n (%) | 201 (9.7) | 359 (13.9) | < 0.001 |
| ICU interventions, n (%) | |||
| Vasopressors | 255 (12.4) | 454 (17.5) | < 0.001 |
| Mechanical ventilation | 269 (13.0) | 327 (12.6) | 0.71 |
| In-hospital recurrent AKI, n (%) | 368 (17.8) | 555 (21.4) | 0.003 |
| In-hospital death, n (%) | 240 (11.6) | 363 (14.0) | 0.02 |
| Hospital length of stay, median (IQR) days | 9 (5, 15) | 10 (6, 16) | < 0.001 |
a
25% albumin.
b
median (IQR) volume given in both groups was 2500 (1000–4500) mL.
Abbreviations: ACLF, acute-on-chronic-liver failure; AKI, acute kidney injury; ICU, intensive care unit; IQR, interquartile range.