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. 2024 Feb 8;15:1176. doi: 10.1038/s41467-024-45274-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Clinical isolates of XBB.1, XBB.1.5, and Delta were inoculated into human iPSC-derived lung organoids. The percentages of HLA-I-positive cells in the lung organoids are shown. B The percentage of HLA-I-positive cells in viral N protein-positive lung organoids is shown. Assays were performed in triplicate. The presented data are expressed as the average ± SD. The statistically significant differences between XBB.1.5 and other variants were determined by a two-sided Student’s t test.