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. 2024 Feb 8;15:1201. doi: 10.1038/s41467-024-45505-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Representative EOM models of the fuzzy interactions between frHMGB1 (cyan cartoon) and CXCL12 (gold surface). b Explicative representations of possible different frHMGB1•CXCL12 conformations bound to CXCR4. Two SAXS-EOM frHMGB1•CXCL12 models have been superimposed on the theoretical model of CXCL12 in complex with CXCR4⁸⁵, with CXCR4 in magenta, CXCL12 in gold surface and frHMGB1 in cyan; the lipid bilayer is represented with cyan spheres and lines.