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. 2024 Feb 8;15:1200. doi: 10.1038/s41467-024-45340-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a mIF of PanCK/UPP1 (UPP1^high/low tumor cells), and CD4/FOXP3 (FOXP3 + CD4 + T cells) (n = 15), representative images shown. b mIF of PanCK/UPP1 (UPP1^high/low tumor cells), and α-SMA/MMP11 (MMP11+ fibroblasts) (n = 15), representative images shown. c mIF of PanCK/UPP1 (UPP1^high/low tumor cells), and CD8/LAG3/PD-1 (LAG3 + PD-1 + CD8 + T cells) (n = 15), representative images shown. d mIF of PanCK/UPP1 (UPP1^high/low tumor cells), and CD68/SPP1 (SPP1 + CD68+ macrophages) (n = 15), representative images shown. The image on the far left represents a panoramic scan, with the ROIs indicating the selected areas. Scale bars = 5 mm. The image on the upper right represents a magnified portion of the white square in the panoramic scan on the left, which is displayed as an original image, classified image, and merged image. Scale bars = 200 μm. The images below represent further magnified views of each antibody staining channel from the selected area. Scale bars = 25 μm. For the ROIs of each section, the spatial distances between the tumor cells and the immune/fibroblast cells were calculated.