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. 2024 Feb 8;30(2):e14601. doi: 10.1111/cns.14601

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© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Construction and testing of the glycolysis‐related glioma signature (GGS). (A) The hub genes were developed using a total of 101 machine‐learning combinations via a 10‐fold cross‐validation framework. The c‐index of each combination was evaluated in all datasets. (B‐E) Time‐dependent ROC analysis revealed the AUC of hub genes for 1‐, 3‐, and 5‐year OS in TCGA‐GBM, CGGA, Rembrandt, and Gravendeel datasets. (F‐I) The distribution of riskscore between five GS in TCGA‐GBM, CGGA, Rembrandt, and Gravendeel datasets.