FIG. 4.

B7-2 Tg mice that had resolved a primary skin infection exhibit enhanced footpad swelling in response to intradermal challenge with C. albicans antigens. (A) Seven days after resolving a primary cutaneous infection with C. albicans (or sham infections), groups of B7-1 Tg, B7-2 Tg, and non-Tg (Ntg) mice (n = 3 mice per group) were challenged with an intradermal injection of 10⁷ HKCA organisms (CA) in sterile PBS (right footpad) or PBS alone (left footpad). (B) Non-Tg mice were immunized with 10⁷ HKCA organisms emulsified in CFA and boosted with similar numbers of C. albicans organisms 1 week later; naive mice served as a negative control. After another week, these animals were challenged with an intradermal injection of 10⁷ HKCA organisms in sterile PBS (right footpad) or PBS alone (left footpad). Change in footpad thickness was followed over time. Data depicted represent the means ± SEM of changes in footpad thickness over time.