TABLE 1.
Strains of L. pneumophilaa
| Strainb | Relative LD50 | Phenotype and genotype | Refer- ence(s) |
|---|---|---|---|
| JR32 | 1 | Mak+ | 37 |
| 25D | >500,000 | Mak− | 17 |
| LELA1802 | >500,000 | Mak−icmX::Tn903dIIlacZ | 34, 37 |
| LELA1984 | 13,000 | Mak−icmE::Tn903dIIlacZ | 34, 37 |
| LELA2474 | 10,000 | Mak−icmU::Tn903dIIlacZ | 34, 37 |
| LELA2955 | >500,000 | Mak−icmX::Tn903dIIlacZ | 34, 37 |
| LELA3118 | >500,000 | Mak−dotA::Tn903dIIlacZ | 34, 37 |
| LELA3150 | 32,000 | Mak−icmB::Tn903dIIlacZ | 34, 37 |
| LELA3278 | 14,000 | Mak−icmR::Tn903dIIlacZ | 37, 38 |
| LELA4004 | >500,000 | Mak−icmX::Tn903dIIlacZ | 34, 37 |
a
Relative LD50s, phenotypes, genotypes, and strain designations are taken from reference 37. Relative LD50s relate to the number of L. pneumophila organisms that are needed to kill one-half of a monolayer of Mφ-like HL-60 cells. Defects in macrophage killing are designated Mak−.
b
All LELA strains are derived from JR32 and contain one Tn903dIIlacZ insertion in the indicated gene.