Table 3.
FISH analysis of hCF-MAC clones
| Clone name | Frequency of metaphase with MAC-hChr translocation (%) | Most frequent karyotype | |
|---|---|---|---|
| CHO HSA6p-MAC1 #01 | 65.0 | 2n, +t(MAC;hChr), +hChr(del) | [10/20] |
| CHO HSA6p-MAC1 #02 | 100.0 | 2n, +t(MAC;hChr), +hChr(del) | [16/20] |
| CHO HSA6p-MAC1 #03 | 100.0 | 2n, +t(MAC;hChr), +hChr(del) | [24/30] |
| CHO HSA6p-MAC1 #04 | 100.0 | 2n, +t(MAC;hChr)x2, +hChr(del) | [20/24] |
| CHO HSA6p-MAC1 #05 | 85.0 | 2n, +t(MAC;hChr), +hChr(del) | [14/20] |
| CHO HSA6p-MAC1 #06 | 100.0 | 2n, +t(MAC;hChr), +hChr(del) | [29/30] |
| CHO HSA21q-MAC2 #01–1 | 90.0 | 2n, +t(MAC;hChr), +hChr(del)x2 | [22/30] |
| CHO HSA21q-MAC2 #01–2 | 85.7 | 8n, +t(MAC;hChr)x4, +hChr(del)x4, +mar(hChr;MAC) | [2/7] |
| CHO HSA21q-MAC2 #01–3 | 100.0 | 2n, +t(MAC;hChr), +hChr(del) | [7/30] |
| CHO HSA21q-MAC2 #01–4 | 94.4 | 2n, +t(MAC;hChr), +hChr(del) | [5/18] |
| CHO HSA21q-MAC2 #02–1 | 46.7 | 2n, +MAC, +hChr | [12/30] |
| CHO HSA21q-MAC2 #02–2 | 0.0 | 2n, +MAC, +hChr | [4/9] |
| CHO HSA21q-MAC2 #02–3 | 66.7 | 2n, +t(MAC;hChr), +hChr(del)x2 | [16/20] |
2n: diploid, 4n: tetraploid, 8n: octoploid, +hChr: additional target human chromosome, +MAC: additional mouse artificial chromosome + t(MAC;hChr): hCF-translocated MAC, +hChr(del): deleted target human chromosome.