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. 2024 Feb 9;30(2):e14609. doi: 10.1111/cns.14609

FIGURE 1.

FIGURE 1

Expression of PTP1B and double immunofluorescence of PTP1B, and NeuN, Iba‐1, and GFAP in the ipsilateral spinal dorsal horn of sham and neuropathic pain rats. (A) Mechanical allodynia was evaluated by the paw withdrawal threshold (PWT) at baseline and 3, 7, and 14 days after surgery. There is no significant difference regarding the PWT among the sham and SNI groups at baseline. However, the PWT in SNI rats was markedly decreased from day 3 to day 14 (*p < 0.05, ****p < 0.0001 compared with sham group, n = 6 in each group, two‐way ANOVA, followed by Bonferroni tests). (B) Western blot results showed that the protein level of PTP1B in the spinal cord of rats with SNI was markedly increased from day 3 to day 14 (****p < 0.0001, n = 6 rats per group, one‐way ANOVA followed by Bonferroni post‐hoc test). (C) Double immunofluorescence of PTP1B and NeuN, Iba‐1, and GFAP in the ipsilateral spinal dorsal horn of sham and SNI rats.