eTable 1. Frequency of clinical symptoms and signs of pulmonary hypertension at the time of diagnosis (e14, e48, e49).
| Symptom/sign | Frequency (%) |
| Dyspnea | 87–98 |
| Loud 2nd heart sound | 93 |
| Fatigue | 26–73 |
| Chest pain/discomfort | 8–48 |
| Systolic murmur (tricuspid regurgitation) | 40 |
| 4th heart sound | 38 |
| Edema | 21–38 |
| Syncope | 8–36 |
| Palpitations | 6–33 |
| Dizziness | 11–26 |
| 3rd heart sound | 23 |
| Cough | 22 |
| Cyanosis | 20 |
| Diastolic murmur (pulmonary insufficiency) | 13 |
| Anxiety | 6 |
| Hemoptysis | 5 |