Table 1.
Descriptive characteristics of eligible, incident new users of overactive bladder medications before and after matching for the primary outcome
| Before matching | After 1:4 (mirabegron:antimuscarinic) matching on hdPS† | |||||
|---|---|---|---|---|---|---|
| Characteristic | Mirabegron (n=5,971) |
Antimuscarinics (n = 21,120) |
Standardized difference‡ |
Mirabegron (n=3,641) |
Antimuscarinics (n =8,993) |
Standardized difference‡ |
| Age, median (IQR) | 77.8 (72.8-83.0) | 77.9 (72.6-83.1) | 0.00 | 77.1 (72.1-82.4) | 77.3 (72.2-82.5) | 0.01 |
| Sex | −0.17 | −0.08 | ||||
| Male | 3,863 (64.7%) | 11,920 (56.4%) | 2,387 (65.6%) | 5,561 (61.8%) | ||
| Female | 2,108 (35.3%) | 9,200 (43.6%) | 1,254 (34.4%) | 3,432 (38.2%) | ||
| Race/Ethnicity | 0.06 | 0.00 | ||||
| White | 5,643 (94.5%) | 19,783 (93.7%) | 3,425 (94.1%) | 8,420 (93.6%) | ||
| Black | 105 (1.8%) | 549 (2.6%) | 63 (1.7%) | 191 (2.1%) | ||
| Other/Unknown | 144 (2.4%) | 486 (2.3%) | 99 (2.7%) | 244 (2.7%) | ||
| Asian | 49 (0.8%) | 165 (0.8%) | 33 (0.9%) | 85 (0.9%) | ||
| Hispanic | 25 (0.4%) | 92 (0.4%) | 19 (0.5%) | 46 (0.5%) | ||
| North Am. Native | 5 (0.1%) | 45 (0.2%) | 2 (0.1%) | 7 (0.1%) | ||
| SDI, median (IQR) | 35.0 (16.0-58.0) | 36.0 (18.0-60.0) | 0.05 | 35.0 (16.0-58.0) | 36.0 (17.0-58.0) | 0.02 |
| Year of OAB medication initiation | 0.66 | 0.25 | ||||
| 2012* | 453 (7.6%) | 5,624 (26.6%) | 309 (8.5%) | 1,226 (13.6%) | ||
| 2013* | ||||||
| 2014 | 834 (14.0%) | 4,001 (18.9%) | 573 (15.7%) | 1,662 (18.5%) | ||
| 2015 | 1,160 (19.4%) | 3,770 (17.9%) | 755 (20.7%) | 1,825 (20.3%) | ||
| 2016 | 1,558 (26.1%) | 3,977 (18.8%) | 929 (25.5%) | 2,172 (24.2%) | ||
| 2017 | 1,966 (32.9%) | 3,748 (17.7%) | 1,075 (29.5%) | 2,108 (23.4%) | ||
| Number of drugs with increased risk of fracture, median (IQR) | 1.0 (1.0-2.0) | 1.0 (1.0-2.0) | 0.08 | 1.0 (0.0-2.0) | 1.0 (0.0-2.0) | 0.02 |
IQR=interquartile range; OAB=overactive bladder; SD=standard deviation; SDI=social deprivation index
†
hdPS includes demographics, predefined variables, and empirically selected variables
‡
Bolded values suggest imbalance between groups
*
Combined due to the Centers for Medicare & Medicaid Services cell suppression policy