TABLE 2.
Treatment effect of multiple oral doses of individual anti-P23 IgA MAbs on C. parvum infection in neonatal mice
| Treatment per os | Mean infection score ± SDa (P value)b
|
|
|---|---|---|
| Expt 1 | Expt 2 | |
| 92.07t | 9.0 ± 1.0 | 8.8 ± 0.9 |
| H8H2 | 5.2 ± 1.1 (<0.001) | NDc |
| H8H12 | 9.6 ± 2.0 (>0.5) | ND |
| F3H6 | 5.8 ± 2.0 (<0.025) | 5.4 ± 1.1 (<0.05) |
| G9H9 | 5.2 ± 1.8 (<0.005) | ND |
| G9H4 | 3.3 ± 1.1 (<0.0001) | 2.4 ± 1.8 (<0.0001) |
| H8H6 | 5.9 ± 1.8 (<0.005) | ND |
a
Scores are based on infection levels in the terminal jejunum, ileum, cecum, and proximal colon (0, absence of infection; 1, 1 to 33% of mucosa parasitized; 2, 34 to 66% of mucosa parasitized; 3, greater than 66% of mucosa parasitized). Cumulative scores that included each intestinal region were calculated for each mouse. The maximum cumulative score per mouse was 12.
b
Compared to C. parvum-infected mice treated with isotype-matched control IgA MAb 92.07t per os.
c
ND, not done.