Table 3.
Demographics and clinical characteristics of subjects in positive control cohorts.
| Subjects | Age at dx (current age) | Sex | Self-Reported Ancestry | Colorectal/Endometrial Cancer | Related syndromic tumor in subject and/or family |
|---|---|---|---|---|---|
| Subject 1 | 46 (55) | F | Irish, Armenian | Colorectal | Mother- Endometrial cancer age 40; Maternal uncle- Colon cancer age 45 |
| Subject 2 | 35 (39) | F | German, Welsh, English, Syrian | Colorectal | Mother- Colon cancer age 59; Maternal uncle- Colon cancer age 42; Maternal male cousin-Colon cancer age 33; Maternal grandmother- Endometrial cancer age 42 and Colon cancer age 62 |
| Subject 3 | 40 & 55 (56) | F | Irish, Italian, Lithuanian | Endometrial and Colorectal | None |
| Subject 4 | 54 (60) | M | Polish, Slovakian | Colorectal | Two brothers- Pancreatic cancer ages 50 and 52; Paternal grandfather- Small intestinal cancer age 37; Paternal male first cousin- Small intestinal cancer age 46 |
| Subject 5 | 51 (56) | M | Chinese | Colorectal | Brother- Colon cancer age 52; Mother- Colon cancer age 64; Maternal uncle- Stomach cancer age 63; Maternal aunt- Colon cancer and Stomach cancer both at age 64 |
| Subject 6 | 33 (34) | F | Emirian | Colorectal | Maternal half-uncle- Colon cancer age 53 |
| Subject 7 | 50 (52) | M | Lebanese, Scottish, Ukrainian, Ashkenazi Jewish | Colorectal | Maternal male uncle- Colon cancer age 72 |
| Subject 8 | 55 & 61 (67) | M | Native American, German, Lithuanian | Colorectal | Subject- Ureter cancer age 55&65; Mother- Pancreatic cancer age 53; Sister- Pancreatic cancer age 51 |
| Subject 9 | 32 (36) | M | Irish, Japanese, African American | Colorectal | Mother- Endometrial cancer age 45 |
| Subject 10 | 62 (64) | M | Italian, Irish, French, German | Colorectal | Sister- Ovarian cancer age 44; Father- Stomach cancer age 65 |
| Subject 11 | 43 (48) | M | Unknown (adopted) | Colorectal | N/A |
| Subject 12 | 29 (37) | F | Indian | Colorectal | N/A |
| Subject 13 | 51 (57) | F | French-Canadian | Colorectal | N/A |
| Subject 14 | 46 (51) | M | French, German | Colorectal | None |
| Subject 15 | 41 (42) | M | Irish, Eastern European, Ashkenazi Jewish | Colorectal | Maternal aunt- Endometrial cancer age 46 |
| Subject 16 | 48 & 64 (69) | F | English, Scottish, Welsh, Austrian, Polish | Endometrial and Colorectal | Brother- Colon cancer age 45; Mother- Bladder cancer age 68 |
| Subject 30 | 40 (52) | F | Portuguese | Endometrial | Paternal aunt- Colon cancer age 58; Two Paternal aunts- Colon cancer unknown ages; Paternal uncle- Colon cancer age 62 |
| Subject 31 | 37 (40) | F | Kuwaiti | Endometrial | Mother- Endometrial cancer age 47 |
| Subject 32 | 71 (76) | F | Irish, English, Scottish, Greek | Endometrial | Subject- Sebaceous adenoma age 69 |
| Subject 33 | 56 (60) | F | Greek | Endometrial | Paternal uncle- GI cancer unknown type; Two paternal male cousins- Colon cancer age 60; Paternal female cousin- Glioblastoma age 46; Paternal male cousin- Glioblastoma age 62; Paternal male cousin- Small intestinal cancer age 58 |
| Subject 34 | 66 (69) | F | Ashkenazi Jewish | Endometrial | Mother- Colon cancer age 82; Maternal uncle- Stomach cancer age 79; Maternal female cousin- Ovarian cancer age 57 |
| Subject 35 | 55 (60) | F | Irish, English, Scottish, African American | Endometrial | Mother- Pancreatic cancer age 53; Maternal uncle- Pancreatic cancer unknown age; Maternal aunt- Pancreatic cancer age unknown age |
| Subject 36 | 51 (56) | F | Ukrainian | Endometrial | None |
| Subject 37 | 39 (42) | F | Portuguese, Spanish | Endometrial | Mother- Endometrial cancer age 52 |
| Subject 38 | 75 (80) | F | French | Endometrial | Mother- Colon cancer age 70 |
| Subject 39 | 67 (72) | F | Latvian, German, Russian, Ashkenazi Jewish | Endometrial | Sister- Endometrial cancer age 60; Maternal first cousin- Ovarian cancer age 58; Maternal first cousin once removed- Pancreatic cancer age 45 |
| Subject 40 | 65 (70) | F | Russian, Belgian, Ashkenazi Jewish, Hungarian, Irish, Spanish | Endometrial | None |
| Subject 41 | 58 (63) | F | Russian, Polish, Lithuanian, Ashkenazi Jewish, English, Irish | Endometrial | Sister- Endometrial cancer age 42; Mother- Kidney cancer age 70 and Glioblastoma age 81; Maternal first cousin- Brain tumor age 27 |
| Subject 42 | 65 (68) | F | English | Endometrial | Father- Colon cancer age 69; Paternal aunt- Endometrial cancer age 85 |
| Subject 43 | 63 (65) | F | Polish, Russian, Irish, German, English | Endometrial | Maternal aunt- Endometrial cancer age 76; Paternal grandmother- Endometrial cancer age 60; Paternal uncle- Brain tumor age 63 |
| Subject 44 | 57 (61) | F | French, Italian | Endometrial | Maternal great grandmother- Colon cancer unknown age |
| Subject 45 | 50 (56) | F | Irish, Italian, Polish | Endometrial | Paternal grandmother- Brain tumor age 58 and Liver cancer age 85; Paternal great uncle- Pancreatic cancer age 78; Paternal great uncle- Liver cancer age 78 |
| Subject 46 | 47 (52) | F | Italian, French-Canadian | Endometrial | Paternal grandfather- Gastrointestinal cancer unknown age |
| Subject 47 | 42 (48) | F | Brazilian | Endometrial | Mother- Endometrial cancer age 42; Nephew- Colon cancer unknown age; Maternal aunt- Endometrial cancer age 62; Maternal first cousin- Endometrial cancer age 55 and Stomach cancer age 55 and Brain tumor age 55; Maternal grandmother- Endometrial cancer age 65; Paternal grandmother- Brain tumor age 69 |
| Subject 48 | 74 (77) | F | French-Canadian, Irish | Endometrial | Maternal first cousin- Kidney cancer age 68 |
| Subject 49 | 45 (49) | F | Polish, German, French, Native American | Endometrial | Paternal grandmother- Colon cancer age 65 |
| Subject 50 | 66 (68) | F | French-Canadian | Endometrial | Father- Colon cancer age 47 and Stomach cancer age 95; Paternal uncle- Stomach cancer age 89; Paternal first cousin- Stomach cancer age 74 |
| Subject 51 | 52 (56) | F | Ashkenazi Jewish | Endometrial | Brother- Kidney cancer age 44; Father-Colon cancer age 60 and Small Intestinal cancer age 73 |
| Subject 52 | 57 (73) | F | Irish, Unknown | Endometrial | Mother- Endometrial cancer age 80 |