Table 5.

Associations between biomarkers of interest and cognition

	β (95% CI)	uncorr-p	FDR-p
CSF IL-6
Entire cohort
Verbal memory	− 0.101 (− 0.290 to 0.087)	0.288	0.576
Executive + speed	− 0.069 (− 0.236 to 0.097)	0.410	0.547
Age ≥ 60
Verbal memory	− 0.045 (− 0.402 to 0.311)	0.798	0.798
Executive + speed	− 0.164 (− 0.432 to 0.105)	0.225	0.450
CSF CRP
Age ≥ 60
Verbal memory	0.187 (− 0.144 to 0.518)	0.260	0.576
Executive + speed	0.027 (− 0.229 to 0.284)	0.830	0.830
Plasma NfL
Age ≥ 60
Verbal memory	0.082 (− 0.212 to 0.375)	0.581	0.775
Executive + speed	− 0.313 (− 0.540 to − 0.086)	0.008**	0.032*

Sensitivity analyses: results from multivariate linear regression models between concentrations of log-transformed biomarker concentration of interest and cognitive factor scores; Verbal Memory and Executive Functioning and Processing Speed. Models were performed within cohorts of interest, based on previous significance with NBD factor scores. Models included covariates: age, BMI, race, total AUDIT score, APOE-ε4 carrier, revised Framingham Stroke Risk Profile score, sleep apnea, and years of education. Results are presented as standardized beta (β), with uncorrected and FDR-corrected p-values

* = p-values ≤ 0.05, ** = p-values ≤ 0.01