Table 1.
Gene List of DNA Methylation/Demethylation and related TIME alter
| Methylation/demethylation | Gene | Immunomodulatory effect | Prognosis | Tumor | PMID |
|---|---|---|---|---|---|
| DNA methylation | NEFM | Positively correlated to macrophage infiltration | Poor prognosis | Breast cancer; Glioma | 3400120832450002 |
| SMARCA4 | Negative correlation with the infiltration of CD8+ T cells | Better prognosis | Pan-cancer | 34675941 | |
| STING1 | Negative correlation with the infiltration of CD8+ T cells | Poor prognosis | Lung cancer | 35978045 | |
| CYTIP | Improving anti-PD-1 immunotherapy | Poor prognosis | NSCLC | 32879421 | |
| TNFSF8 | Improving anti-PD-1 immunotherapy | Poor prognosis | NSCLC | 32879421 | |
| GPC2 | Positively correlated with infiltrated T cells, auxiliary T cells, Tcm, Th17 cells and Th2 cells | Poor prognosis | Bladder cancer, Breast cancer | 35345673 | |
| TNFRSF9 | positively correlated with immune cell infiltrates and an interferon-γ signature | Poor prognosis | Melanoma | 3202068 | |
| RNF135 | Positively correlated with B cells, CD4 T cells, macrophages and dendritic cells | Poor prognosis | Hepatocellular carcinoma | 35145901 | |
| DNA demethylation | FOXP3 | Regulate the stability and inhibition function of Tregs, and directly regulate the amplification and function of T cells | Poor prognosis | NSCLC | 27000869 |
| FOXP1 | Regulate macrophage hypoxia | Better prognosis | NSCLC | 30100403 | |
| Tenascin-C | the morphology and function of TAM | Poor prognosis | Glioma | 32845507 | |
| DDOST | Negative correlation with the infiltration of B cells and CD4+ T cells | Poor prognosis | Glioma | 35812432 | |
| ERBB2 | suppress induction and proliferation of effector T cells | Poor prognosis | Pan-cancer | 36172165 | |
| APOBEC3H | CD8+ T cell immune infiltration and activation | Better prognosis | Squamous cell carcinoma of the head and neck | 32775421 |