Table 3.

The list of DNA methyltransferase inhibitors and related TIME or tumor alter

DNMTi	Function	Combined use	Tumor	PMID
Decitabine	Increased expression of cancer-testis antigens	–	Ovarian cancer	26098711
	Tumor cell lysis by CTL	PD-L1/PD-1 blocker	Rhabdomyosarcoma	32528824
	Increased memory T cell infiltration and up-regulation CTLA-4 and FOXP3	ipilimumab	Melatoma	36706355
	CTL-mediated tumor cell killing	IFN-γ	Neuroblastoma	21626030
	PD-1 blocking	Pembrolizumab	Leukemia	35017151
	Increased B lymphocytes	CAR-T	Lymphoma	36059523
	Enhance the secretion of ifn-γ and mage-a3 antigen-sive t cells	–	Esophageal squamous cell carcinoma	30797153
	Upregulation the genes involved in congenital and adaptive immunity and PD-L1	Nivolumab	NSCLC	34140403
	Reverse the depletion of CD8+ TIL and improve T cell response	Nivolumab	gastric cancer	35024441
Azacytidine	Inducing apoptosis of p53-dependent cells	Nivolumab	squamous cell carcinoma of the head and neck	28916527
	Down-regulate B-cell lymphoma 2	venetoclax	Acute myelogenous leukemia	32054729
	Reduce the suppressive function of Tregs	–	Myelodysplastic syndrome	23242597
	Upregulate the genes involved in congenital and adaptive immunity and PD-L1	Nivolumab	NSCLC	29195073
	Increased plasma HMGB1 expression	–	Osteosarcoma	29097772
Zebularine	Promote the infiltration of CD8 T cells and NK cells	–	Myeloma	32394351
Hydralazine	Upregulate HLA-1 antigen expression and antigen-specific CTL response	Valproic acid	Cervical cancer	17192185
	Induce ICD and CTL infiltration	bortezomib	Pan-cancer	36031455
EGCG	Reduce TAM to inhibit tumor growth	Genistein	Pan-cancer	31877341