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. 2024 Feb 9;24:177. doi: 10.1186/s12879-024-09046-0

Table 5.

A brief list of HTL Epitopes to form the final structure of the vaccine

specie epitopes protein antigenicity allergenicity IFN-γ IL4 toxicity epitope conservancy
hit (maximum identity %)
human homology interacting MHC-II alleles
HPyV6 VAAQRRVLMLESTRQ LTAg 0.8394

probable

non-allergen

positive inducer non-toxic 100 non-homologue HLA-DRB1*04:10, HLA-DRB1*04:04, HLA-DRB1*04:05, HLA-DRB1*04:08
GLVNLVNYAVNYNRQ VP2 0.7212

probable

non-allergen

positive inducer non-toxic 100 non-homologue HLA-DRB1*08:06, HLA-DRB1*01:02, HLA-DRB1*08:13, HLA-DRB1*13:04, HLA-DRB1*08:01, HLA-DRB1*04:23
GRFFRVHFRQRRVKH VP1 0.4931

probable

non-allergen

positive inducer non-toxic 100 non-homologue HLA-DRB1*11:20, HLA-DRB1*11:14, HLA-DRB1*13:23, HLA-DRB1*08:04, HLA-DRB5*01:01, HLA-DRB5*01:05
SAGYIRAQGTPAGVE VP1 0.8598

probable

non-allergen

positive inducer non-toxic 100 non-homologue HLA-DRB1*09:01
HPyV7 DWNFVADFAADMELT LTAg 1.2109

probable

non-allergen

positive inducer non-toxic 100 non-homologue HLA-DRB3*01:01, HLA-DRB1*03:09, HLA-DRB1*03:05, HLA-DRB1*04:21
FEPGGVVMYDTQNLP VP2 0.9125

probable

non-allergen

negative inducer non-toxic 100 non-homologue HLA-DRB1*15:06, HLA-DRB1*04:02, HLA-DRB1*08:06, HLA-DRB1*15:02, HLA-DRB1*08:04, HLA-DRB1*08:13, HLA-DRB1*04:10, HLA-DRB1*08:01
FFRVHCRQRRIKHPY VP1 0.4266

probable

non-allergen

negative inducer non-toxic 100 non-homologue HLA-DRB5*01:05, HLA-DRB1*11:20, HLA-DRB1*11:14, HLA-DRB1*13:23