Table 3.
Univariate and multivariate analyses of subsequent psychiatric disease incidences in full term infants with or without the diagnosis of low birth weight (birth weight between 2000 to 2500 g) (N = 100,120)
| variable | MLBW (n = 50,060) | No MLBW (n = 50,060) | Univariate model | Multivariate modela | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of participants | No. of participants | Crude HR | (95% CI)b | p value | Adjusted HR | (95% CI)b | p value | |||
| Any psychiatric disorders | 8660 | 6695 | 1.36 | 1.36 | 1.40 | < 0.001 | 1.33 | 1.29 | 1.37 | < 0.001 |
| Specific delay in development or mental retardation | 7109 | 5290 | 1.40 | 1.35 | 1.46 | <0 .001 | 1.38 | 1.33 | 1.43 | <0 .001 |
| Attention deficit and hyperactivity disorder | 3359 | 2690 | 1.27 | 1.20 | 1.34 | <0 .001 | 1.26 | 1.20 | 1.33 | < 0.001 |
| Adjustment disorders | 240 | 228 | 1.05 | 0.88 | 1.26 | 0.58 | 1.05 | 0.88 | 1.26 | 0.58 |
| Afftve disorders | 12 | 8 | 1.50 | 0.61 | 3.67 | 0.37 | 1.50 | 0.61 | 3.67 | 0.37 |
| Anxiety disorders | 319 | 292 | 1.09 | 0.93 | 1.28 | 0.27 | 1.09 | 0.93 | 1.28 | 0.27 |
| Autism spectrum disorders | 854 | 677 | 1.27 | 1.14 | 1.40 | < 0.001 | 1.26 | 1.14 | 1.40 | <0 .001 |
| Conduct disorders | 234 | 188 | 1.25 | 1.03 | 1.51 | 0.03 | 1.25 | 1.03 | 1.51 | 0.02 |
| Emotional disturbance | 704 | 622 | 1.13 | 1.02 | 1.26 | 0.02 | 1.13 | 1.02 | 1.26 | 0.02 |
| Personality disorders | 14 | 6 | 2.33 | 0.90 | 6.07 | 0.08 | 2.33 | 0.90 | 6.07 | 0.08 |
| Psychosis | 5 | 0 | 1.50 | 0.25 | 8.98 | 0.66 | 1.50 | 0.25 | 8.99 | 0.66 |
| Schizophrenia | 0 | 0 | ||||||||
MLBW marginally low birthweight, defined as term-born infants with birth weight between 2000 and 2499 grams. No MLBW: term-born infants with birth weight 2500 grams
a Multivariate Cox proportional hazard model, adjusted for all covariates from Table 2. b No MLBW is reference group