Table 2.

Odds ratios of risk of Sjögren’s disease diagnosis according to conditional logistic regression models

Predictor	Odds Ratio (95% Confidence Interval)	p-value
Conditional Logistic Regression Model Based on EHR Data
Drug Class: Antimalarials	1.88 (0.18, 19.51)	0.598
Drug Class: Glucocorticosteroids	1.36 (0.62, 2.97)	0.448
Drug Class: Nonsteroidal Anti-inflammatory Agents (NSAIDs)	1.23 (0.62, 2.45)	0.555
Drug Class: Throat Products - Misc.	13.14 (2.49, 69.26)	0.002
Diagnosis: Depressive disorder	1.29 (0.62, 2.66)	0.494
Diagnosis: Myalgia and myositis/Fibromyalgia	1.79 (0.71, 4.53)	0.215
Diagnosis: Pain in joints	2.36 (1.27, 4.37)	0.006
Diagnosis: Systemic lupus erythematosus	2.60 (0.30, 22.27)	0.382
Diagnosis: Tear Film Insufficiency	32.35 (6.21, 168.63)	< 0.001
Laboratory Test: Rheumatoid Factor	7.09 (2.02, 24.81)	0.002
Dry Mouth	6.91 (2.41, 19.82)	< 0.001
Conditional Logistic Regression Model Based on Integrated EHR and EDR Data
Drug Class: Antimalarials	2.10 (0.18, 24.03)	0.552
Drug Class: Glucocorticosteroids	1.66 (0.74, 3.75)	0.223
Drug Class: Nonsteroidal Anti-inflammatory Agents (NSAIDs)	1.15 (0.57, 2.34)	0.699
Drug Class: Throat Products - Misc.	14.97 (2.70, 83.06)	0.002
Diagnosis: Myalgia and myositis/Fibromyalgia	1.50 (0.58, 3.90)	0.403
Diagnosis: Pain in joints	2.53 (1.34, 4.76)	0.004
Diagnosis: Systemic lupus erythematosus	2.17 (0.23, 20.15)	0.496
Diagnosis: Tear Film Insufficiency	27.04 (5.37, 136.26)	< 0.001
Dental Procedure: Diagnostic	0.45 (0.20, 1.01)	0.053
Dental Procedure: Surgery	2.33 (1.14, 4.78)	0.021
Laboratory Test: Rheumatoid Factor	6.97 (1.94, 25.12)	0.003
Dry Mouth	6.19 (2.14, 17.89)	< 0.001

Model selection was performed using LASSO for conditional logistic regression models