Table 2.

Investigations involving Types of AQPs with the respective inhibitory molecules for specific Cancer cell lines

AQPs	Inhibitory molecule	Type of Study/Studied on	Inhibited Process/Outcome	Reference
AQP1	Ion channel Blocker	H2T9	Cell Migration	[60]
	Carbonic Anhydrase inhibitor-Acetazolamide	Glioma cell line	Invasion and angiogenesis	[81, 87]
	AQB050	primary malignant mesothelioma cells	Reduction in cell growth	[89]
	cyclophosphamide, topiramate and anaesthetic drugs		AQP1 inhibitors	[181]
	Rg3	PC-3 M prostate cancer cell line	Inhibited p38 MAPK pathway	[92]
	Tetraethyl ammonium	J82 human bladder cancer cells	Blocks AQP1	[95]
	microRNA-320 AQP1 siRNA	LTEP-A2 and LLC lung cancer cell lines; HMEC-1 human endothelial cells	Downregulating matrix metalloprotease; Lack of F-actin polarisation	[68, 79, 80]
	shRNA	U2OS and MG63 osteosarcoma	Decrease in proliferation, Reduced TGF-B signalling	[31]
AQP2	Oestrogen receptor blocker ICI182780	Ishikawa cells in human Endometrial cancer	Reduced invasion, proliferation and migration	[33]
AQP3	RNAi	XWLC-05 Lung cancer cells Pancreatic BXPC3, HPAFII MDA-IBC3 breast cancer cell lines	Reduced proliferation and invasion Reduced cell growth and proliferation Diminished tumour migration	[122, 124, 133]
	Auphen and dbcAMP	DU-135 & PC-3 prostate cancer cells HCC cells	Reduced matrixmetalloprotease3 Reduced HCC development	[129]
	Curcumin	CaOV3 ovarian cell line	Reduced cell migration	[132]
AQP4	siRNA mediated knockdown; Monoclonal AQP4-IgG conjugated with toxin	Glioblastoma cells	Cellular apoptosis and Selective cytotoxicity respectively	[11, 142, 143]
AQP5	RNAi	MCF7 Breast cancer cell line Tounge SCC cell line LAMA84 CML cells	Reduced cell migration & proliferation Decreased cell migration Reduced cell proliferation	[45, 48, 156]
	Short hairpin RNA	Lung adenocarcinoma SPCA1 cell line	Reduced cell migration	[159]
	P38 MAPK inhibitor	HT-29 cells colon cancer	Reduced p38 phosphorylation	[160]
	Cairicoside E	Colon cancer cells	Decreased EMT	[163]
	Acetazolamide	Gastric cancer cells	Reduced proliferation and invasiveness	[51, 52]
	HgCl2	MKN45 gastric cancer cells	Reduced number of differentiated cells	[164]
	miR-1226–3p, miR-19a-3p, and miR-19b-3p	Breast cancer cells	Reduced cell motility	[167]
	Epigallectocatechin gallate	SKOV3 ovarian cancer cells	Promoted apoptosis and inhibited cell proliferation	[175]