Table 4:

Incident all-cause dementia, AD, and vascular dementia during five time periods after cancer diagnosis

Outcome	No. of events /person-yearsa	HR	95% CI	HR	95% CI	HR	95% CI
		Model 1b		Model 2c		Model 3d
All-cause dementia
No cancer	2,640/1,432,923	1.00	ref.	1.00	ref.	1.00	ref.
0-1 years	65/16,960	1.83	1.42-2.35	1.80	1.40-2.31	1.83	1.42-2.36
1-5 years	147/60,253	1.04	0.88-1.24	1.03	0.87-1.22	1.03	0.87-1.23
5-10 years	163/57,353	1.10	0.93-1.29	1.06	0.90-1.25	1.04	0.88-1.23
10-20 years	190/63,426	1.10	0.95-1.28	1.04	0.90-1.21	1.04	0.89-1.22
>20 years	105/40,991	1.06	0.87-1.29	1.03	0.84-1.26	1.06	0.87-1.30
AD dementia
No cancer	1,222/1,437,116	1.00	ref.	1.00	ref.	1.00	ref.
0-1 years	35/17,018	2.22	1.57-3.12	2.18	1.55-3.08	2.16	1.52-3.08
1-5 years	57/60,454	0.88	0.68-1.16	0.88	0.67-1.15	0.87	0.66-1.15
5-10 years	64/57,600	0.94	0.73-1.21	0.92	0.71-1.19	0.91	0.70-1.18
10-20 years	78/63,710	0.91	0.72-1.16	0.88	0.70-1.12	0.88	0.69-1.13
>20 years	52/41,172	1.06	0.80-1.41	1.04	0.78-1.38	1.09	0.82-1.46
Vascular dementia
No cancer	664 /1,438,617	1.00	ref.	1.00	ref.	1.00	ref.
0-1 years	17/17,036	1.98	1.22-3.21	1.96	1.21-3.18	2.10	1.29-3.41
1-5 years	38/60,554	1.10	0.79-1.52	1.08	0.78-1.50	1.13	0.81-1.57
5-10 years	55/57,664	1.41	1.07-1.87	1.37	1.03-1.81	1.31	0.98-1.76
10-20 years	43/63,830	0.98	0.72-1.34	0.93	0.68-1.27	0.97	0.71-1.34
>20 years	33/41,209	1.26	0.87-1.83	1.22	0.84-1.78	1.28	0.87-1.87

Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; HR, hazard ratio.

^aNumber of dementia cases divided by follow-up time (person-years) in the cancer group.

^bAdjusted for sex, race, and the presence of the APOE-ε4 allele, stratified by assessment center.

^cFurther adjusted for education, Townsend deprivation index, and the number of clinic visits.

^dFurther adjusted for BMI, ever used alcohol, physical activity, diabetes, and stroke, further stratified by ever smoked.