Table 1:

Demographic, radiological, biochemical, surgical and pathology examination characteristics of patients undergoing adrenalectomy

Patient	Sex/Age at adrenal lesion diagnosis	Morphology/Size	Indication for surgery	Treatment timing	Functional status	Surgical approach	Pathology	Outcome
1	Male/29	Single nodule/80 mm	Pheochromocytoma	Upfront surgery	Functioning (Pheochromocytoma)	Open anterior total adrenalectomy	Pheochromocytoma/adrenocortical hyperplasia	No pheochromocytoma recurrence at 2-year follow-up
2	Male/54	Single nodule/123 mm	Adrenocortical carcinoma	Upfront surgery	Functioning (Hyperandrogenism)	Open anterior total adrenalectomy	Adrenocortical carcinoma	Death by metastatic disease at 5-year follow-up
3	Male/24	- Left: single nodule/21 mm - Right: Single nodule/15 mm	-Left: size 21 mm -Right: Nodule hypervascularity	Left: Upfront surgery Right: Follow-up	Nonfunctioning	Left: Open anterior total adrenalectomy Right: Open anterior cortical-sparing adrenalectomy	-Left: Nodular hyperplasia -Right: Adrenocortical hyperplasia	-Left: 14-year follow-up without recurrence -Right: 6-year follow-up without recurrence
4	Female/52	Single nodule/28 mm	Size and concomitant planned distal pancreatectomy	Upfront surgery	Nonfunctioning	Open anterior total adrenalectomy	Adrenocortical adenoma	5-year follow-up without recurrence
5	Male/58	Single nodule/62 mm	pNET extension	Upfront surgery	Not evaluated	Open anterior total adrenalectomy	Invasive pNET	11-year follow-up without recurrence
6	Female/43	Single nodule/33 mm	Enlargement	Follow-up	Nonfunctioning	Retroperitoneoscopic total adrenalectomy	Adrenal cortical neoplasm with oncocytic features, Ki-67 index 12.5%	7-months follow-up without recurrence
7	Male/48	Single nodule/63 mm	Enlargement	Follow-up	Nonfunctioning	Open anterior total adrenalectomy	Adrenocortical carcinoma	1-year follow-up without recurrence
8	Female/31	Single nodule/40 mm	Pheochromocytoma	Upfront surgery	Functioning (Pheochromocytoma)	Open anterior total adrenalectomy	Pheochromocytoma	8-year follow-up without pheochromocytoma recurrence, death by metastatic gastrinoma
9	Male/44	Bilateral hyperplasia	Medical treatment failure	Follow-up	Functioning (ACTH dependent hypercortisolism)	Retroperitoneoscopic bilateral adrenalectomy	Bilateral adrenal cortical hyperplasia	1-year follow-up with hypercortisolism resolution. Death by metastatic thymic neuroendocrine tumor
10	Male/56	Bilateral hyperplasia	Medical treatment failure	Follow-up	Functioning (ACTH dependent hypercortisolism)	Anterior laparoscopic, converted to open anterior, bilateral adrenalectomy	Bilateral adrenal cortical hyperplasia	Death by postoperative pulmonary complications
11	Male/51	Single nodule/76 mm	Size	Upfront surgery	Not evaluated	Anterior laparoscopic total adrenalectomy	Adrenal gland cyst
12	Female/32	-Left: Single nodule/31 mm -Right: Single nodule/20 mm	Enlargement	Follow-up	Nonfunctioning	-Left: Anterior laparoscopic total adrenalectomy -Right: Anterior laparoscopic total adrenalectomy	-Left: Atypical myxoid adrenal cortical neoplasm -Right: Atypical myxoid adrenal cortical neoplasm	-Left: 5-year follow-up without recurrence -Right: 1-year follow-up without recurrence

pNET, pancreatic neuroendocrine tumor