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. 2024 Feb 6;16(1):2307542. doi: 10.1080/19490976.2024.2307542

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 10. — CAR-claudin18.2⁺ CD8⁺ T cells were administered in conjunction with 0.5 mmol/L Butyrate for the treatment of subcutaneous MGC-803 tumors. groups: Mock T, CAR-T, CAR-T+Bu. (a) Analysis of body weight fluctuations. (b) Live imaging statistical analysis of (C). (c) In vivo imaging conducted on days 0, 5, 10, 15, and 21. (d) Tumor size was measured after 23 days of treatment. (e-f) Flow cytometry analysis revealed the proportion of CD8⁺ T cells within the tumor. (g) Hematological analysis showed variations in WBC, RBC, HGB, and PLT. (h) Blood biochemistry examination reflected changes in ALT, AST, ALP, and BUN levels. The data represent the mean ± SD. *p < .05, **p < .01, and ***p < .001, as determined by a two-tailed Student’s t-test or one-way ANOVA.