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. 2023 Sep 1;9(35):eadg7053. doi: 10.1126/sciadv.adg7053

Fig. 7. MAVI1 interaction with MAVS is critical for MAVI1 function in regulating antiviral innate immune responses.

Fig. 7.

(A) Schematic representation of Flag-tagged MAVI1 and Flag-tagged MAVI1 with the lysosome sorting signal from LAMP1 attached (MAVI1-Lyso) is shown. (B) HEK293 cells transfected with Flag-tagged MAVI1-lyso were subjected to immunofluorescence analysis using anti-Flag (red) and anti-LAMP1 antibody (green). (C) HEK293 cells transfected with vectors as indicated were subjected to IB analysis. (D) HEK293 cells as described in (C) were subjected to examination of IFNB1, CCL5, and CXCL10 expression (mean ± SEM, ***P < 0.001). (E) HEK293 cells transfected with vectors as indicated were subjected to IB analysis. (F) HEK293 cells as described in (E) were subjected to examination of IFNB1, CCL5, and CXCL10 expression (mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001).