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. 2023 Sep 1;9(35):eadg5234. doi: 10.1126/sciadv.adg5234

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Fig. 4. — (A) mRNA turnover assay to measure the mRNA half-life transcripts in epidermal progenitors demonstrates prolonged half-life of SETD1A, SETD1B, and KMT2B transcripts with METTL3 depletion. KMT2D transcripts shows a trend of prolonged half-life with METTL3 depletion. Transcripts were normalized by glyceraldehyde-3-phosphate dehydrogenase. DMSO, dimethyl sulfoxide. (B) Immunoblotting of Mettl3 in control versus Mettl3-eKO P6 mouse epidermis. (C) High-molecular weight Western blot for Setd1a in P6 mouse epidermis. (D) IHC for Setd1a in P6 mouse epidermis. (E) IHC for H3K4me2 in P6 mouse epidermis. (F) IHC for H3K4me3 in P6 mouse epidermis.