Fig. 5. Schematic of Mettl3-mediated m⁶A gene regulation in self-renewing stratifying epithelial tissues.

Loss of the Mettl3-m⁶A epitranscriptome promotes the up-regulation of chromatin modifiers by reducing mRNA degradation to promote increased mRNA half-life. This up-regulation of chromatin modifiers and, in turn, their associated histone modifications leads to dysfunctional epidermal development and differentiation.