Table 7.

ADME properties of compounds 7h, 7i, 7j, 7k, and 7l.

Compd.	GI abs.	BBB	P-gp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
7h	High	Yes	No	Yes	Yes	Yes	No	No
7i	High	Yes	No	Yes	Yes	Yes	No	No
7j	High	Yes	No	Yes	Yes	Yes	No	No
7k	High	No	No	Yes	Yes	Yes	No	Yes
7l	High	No	No	Yes	Yes	Yes	No	Yes