Figure 2.

DRST. This figure illustrates the decision tree generated for DRST. There are 11 nodes that are labeled from Node 0 to Node 10 where Node 0 is the root node. At each splitting node (Nodes 0, 1, 3, 6, 8), one of the three patient baseline characteristics is chosen and its distribution is shown in a scatter plot: patient age at the index (age), three-month average LDL-C before the index (ldl_pre), and age-adjusted Charlson score before the index (dchar_score_age). The x-axis of the distribution scatter plots represents the value range of the chosen patient baseline characteristics (age, ldl_pre, or dchar_score_age) while the y-axis represents the statin treatment plans. The different statin treatment plans are also represented in different colors. By following the splitting criteria on the left or right paths of the splitting nodes, six identified subpopulations can be found in the six leaf nodes (Nodes 2, 4, 5, 7, 9, and 10). The pie charts at the leaf nodes represent the distribution of the recommended statin treatment plans from the PSTP strategy. The majority votes are displayed underneath each of the pie charts and they represent the six optimal statin treatment plans that can maximize the benefits of LDL-C reduction and minimize the risks of SAS and discontinuation for each of the identified subpopulations, respectively.