Table 4.
Arterial blood and haemodynamic values in the plasma and enalaprilat infusion fetal heart model
| Group | Day 0 | Day 8 | P vs. Day 8 control | |
|---|---|---|---|---|
|
| ||||
| pH | Control | 7.36 ± 0.02 | 7.36 ± 0.02 | |
| Enalaprilat | 7.35 ± 0.01 | 7.21 ± 0.09 | 0.64 | |
| Plasma | 7.37 ± 0.02 | 7.36 ± 0.01 | 0.999 | |
| PCO2 (mmHg) | Control | 52.6 ± 2.4 | 52.0 ± 1.2 | |
| Enalaprilat | 47.2 ± 2.1 | 52.9 ± 5.1 | 0.879 | |
| Plasma | 51.5 ± 3.0 | 51.3 ± 2.5 | 0.924 | |
| PO2 (mmHg) | Control | 22.8 ± 1.1 | 23.1 ± 3.2 | |
| Enalaprilat | 21.3 ± 3.4 | 16.8 ± 1.5 | 0.013 | |
| Plasma | 23.5 ± 2.0 | 20.3 ± 4.0 | 0.292 | |
| Haematocrit (%) | Control | 31.3 ± 2.8 | 30.1 ± 2.2 | |
| Enalaprilat | 32.4 ± 3.1 | 33.5 ± 4.5 | 0.3219 | |
| Plasma | 35.4 ± 5.6 | 34.1 ± 4.6 | 0.225 | |
| Total haemoglobin (g/dl) | Control | 9.8 ± 1.1 | 8.9 ± 0.5 | |
| Enalaprilat | 8.9 ± 1.7 | 9.2 ± 2.1 | 0.920 | |
| Plasma | 10.5 ± 1.6 | 10.0 ± 1.1 | <0.0001 | |
| O2 content (ml/100ml) | Control | 7.3 ± 0.7 | 6.5 ± 0.5 | |
| Enalaprilat | 7.3 ± 2.3 | 6.2 ± 2.2 | 0.916 | |
| Plasma | 7.3 ± 0.9 | 5.1 ± 0.7 | 0.221 | |
| Protein (g/100ml) | Control | 3.4 ± 0.2 | 3.6 ± 0.1 | |
| Enalaprilat | 3.2 ± 0.2 | 3.3 ± 0.1 | 0.052 | |
| Plasma | 3.3 ± 0.2 | 7.4 ± 0.3 | < 0.0001 | |
| Aortic pressure (mmHg) | Control | 41.3 ± 0.9 | 41.3 ± 1.9 | |
| Enalaprilat | 40.9 ± 3.1 | 30.2 ± 7.4 | 0.009 | |
| Plasma | 41.6 ± 2.1 | 61.0 ± 4.5 | < 0.0001 | |
| Atrial pressure (mmHg) | Control | 2.0 ± 0.7 | 2.5 ± 0.9 | |
| Enalaprilat | 2.1 ± 0.8 | 1.9 ± 0.5 | 0.3745 | |
| Plasma | 1.9 ± 0.6 | 3.0 ± 0.8 | 0.4908 | |
| Heart rate (beats/min) | Control | 167 ± 7 | 143 ± 13 | |
| Enalaprilat | 163 ± 15 | 156 ± 29 | 0.486 | |
| Plasma | 171 ± 12 | 157 ± 11 | 0.439 | |
Values are presented at Day 0 and Day 8 of the intervention. Data presented as means ± SD, with P-values as indicated. Statistical comparisons were made vs. control using 1-way ANOVA with Dunnett’s multiple comparison test. n = 5 animals in all groups.