Table 1.
Patient demographics and baseline characteristics.
| Parameter | ITT (n = 69) | |
|---|---|---|
| Age at study entry (years) | Median (range) | 78 (55–88) |
| <60 years | n (%) | 2 (2.9%) |
| ≥60 years | n (%) | 67 (97.1%) |
| Gender | ||
| Female | n (%) | 30 (43.5%) |
| Male | n (%) | 39 (56.5%) |
| ECOG PS | ||
| Grade 0 | n (%) | 22 (31.9%) |
| Grade 1 | n (%) | 38 (55.1%) |
| Grade 2 | n (%) | 9 (13.0%) |
| QLQ-C30 score 1 | ||
| Summary score | Median (range) | 72.2 (22.3–99.5) (n = 67) |
| Global health status | Median (range) | 58.3 (8.33–100) (n = 66) |
| Functional scales | ||
| Physical functioning | Median (range) | 66.7 (6.67–100) (n = 67) |
| Role functioning | Median (range) | 66.7 (0–100) (n = 67) |
| Emotional functioning | Median (range) | 66.7 (0–100) (n = 67) |
| Cognitive functioning | Median (range) | 100 (16.7–100) (n = 67) |
| Social functioning | Median (range) | 66.7 (0–100) (n = 67) |
| Symptom scales/items | ||
| Fatigue | Median (range) | 44.4 (0–100) (n = 67) |
| Nausea and vomiting | Median (range) | 0 (0–100) (n = 67) |
| Pain | Median (range) | 33.3 (0–100) (n = 67) |
| Dyspnea | Median (range) | 33.3 (0–100) (n = 67) |
| Insomnia | Median (range) | 33.3 (0–100) (n = 67) |
| Appetite loss | Median (range) | 33.3 (0–100) (n = 67) |
| Constipation | Median (range) | 33.3 (0–100) (n = 67) |
| Diarrhea | Median (range) | 0 (0–100) (n = 67) |
| Financial difficulties | Median (range) | 0 (0–100) (n = 67) |
| IADL total score | Median (range) | 8 (2–8) (n = 68) |
| Patients with restrictions (<8) | n (%) | 32 (46.4%) |
| Patients without restrictions (8) | n (%) | 36 (52.2%) |
| MNA total score | Median (range) | 27 (11–33) (n = 68) |
| Normal (≥24) | n (%) | 55 (79.7%) |
| Risk of malnutrition (17–23.5) | n (%) | 10 (14.5) |
| Malnutrition (<17) | n (%) | 3 (4.3%) |
| CCI total score | Median (range) | 8 (0–14) (n = 59) |
| Low mortality risk (≤2) | n (%) | 12 (17.4%) |
| High mortality risk (>2) | n (%) | 47 (68.1%) |
| GDS total score | Median (range) | 3 (0–10) (n = 65) |
| Normal (0–5) | n (%) | 59 (85.5%) |
| Light-to-moderate depression (6–10) | n (%) | 6 (8.7%) |
| Severe depression (11–15) | n (%) | 0 |
| G8 total score | Median (range) | 13 (5–16) (n = 68) |
| Geriatric care needed (≤14) | n (%) | 50 (72.5%) |
| No geriatric care needed (>14) | n (%) | 18 (26.1%) |
| TUG (Time in s) | Median (range) | 8.0 (1–17) (n = 54) |
| Severe mobility restriction (≥30 s) | n (%) | 0 |
| Significant mobility restriction (20–29 s) | n (%) | 0 |
| Moderate mobility restriction (11–19 s) | n (%) | 15 (21.7%) |
| No mobility restriction (<10 s) | n (%) | 39 (56.5%) |
| CARG total score | Median (range) | 7.0 (0–18) (n = 62) |
| Low risk for side effects (0–5) | n (%) | 26 (37.7%) |
| Intermediate risk for side effects (6–9) | n (%) | 20 (29.0%) |
| High risk for side effects (>9) | n (%) | 16 (23.2%) |
1 For QLQ-C30, all of the scales and single-item measures range in score from 0 to 100. A high score for the global health status/QoL represents a high QoL. A high score for a functional scale represents a high/healthy level of functioning, but a high score for a symptom scale/item represents a high level of symptomatology/problems.