Table 3.
OS | Time to Onset of Response | Duration of Response | |
---|---|---|---|
Factor | HR [95% CI], p-Value | HR [95% CI], p-Value | HR [95% CI], p-Value |
Age ≥ 78 | 1.130 [0.610; 2.095], 0.697 | 2.251 [0.788; 6.430], 0.130 | 0.700 [0.182; 2.691], 0.604 |
Sex (male) | 1.169 [0.634; 2.155], 0.617 | 0.942 [0.339; 2.617], 0.909 | 1.068 [0.259; 4.401], 0.928 |
ECOG PS Grade 1 | 1.270 [0.634; 2.544], 0.501 | 0.951 [0.299; 3.028], 0.933 | 1.081 [0.205; 5.700], 0.927 |
ECOG PS Grade 2 | 1.664 [0.643; 4.309], 0.294 | 2.263 [0.409; 12.530], 0.350 | 0.230 [0.017; 3.114], 0.269 |
QLQ-C30 summary score > 72.2 | 0.698 [0.377; 1.292], 0.252 | 5.462 [1.325; 22.51], 0.019 | 2.192 [0.505; 9.517], 0.295 |
IADL at least one restriction | 1.516 [0.831; 2.763], 0.175 | 1.241 [0.446; 3.452], 0.680 | 0.858 [0.244; 3.014], 0.811 |
MNA malnutrition | 2.663 [0.627; 11.310], 0.185 | 1.226 [0.149; 10.097], 0.850 | 0.873 [0.099; 7.693], 0.902 |
MNA risk of malnutrition | 2.288 [0.917; 5.714], 0.076 | 0.787 [0.215; 2.880], 0.717 | 6.232 [1.022; 37.996], 0.047 |
CCI > 2 (high mortality risk) | 0.966 [0.403; 2.316], 0.937 | 1.113 [0.298; 4.152], 0.874 | 0.311 [0.056; 1.740], 0.184 |
GDS moderate | 1.764 [0.688; 4.522], 0.237 | 2.966 [0.331; 26.61], 0.331 | 3.534 [0.366; 34.100], 0.275 |
G8 ≤ 14 | 1.025 [0.524; 2.005], 0.943 | 0.717 [0.252; 2.037], 0.532 | 1.907 [0.489; 7.446], 0.353 |
CARG intermediate (6–9) | 1.298 [0.633; 2.661], 0.476 | 1.100 [0.328; 3.688], 0.878 | 0.217 [0.024; 1.992], 0.177 |
CARG high (>9) | 0.752 [0.318; 1.778], 0.516 | 0.483 [0.119; 1.965], 0.310 | 10.12 [1.042; 98.337], 0.046 |
TUG moderate restriction | 1.987 [0.971; 4.063], 0.060 | 0.602 [0.126; 2.865], 0.524 | 1.691 [0.188; 15.250], 0.639 |
OS—overall survival; HR—hazard ratio; CI—confidence interval.