Table 6.

Hypofractionation for lung NSCLC.

Trial	Sample Size	Inclusion Criteria	RT Technique	Fractionation	Outcomes	Median Follow-Up	Results
SOCCAR [98]	130	Stage III	3D/IMRT 4D CT allowed	55Gy/20 fx Concurrent vs. sequential chemo	TRTM	2.93 years	TRTM 2.9% (CI 0.36–10.2%) concurrent vs. 1.7% (CI 0.043–9.1%) sequential; RR 1.25 (CI 0.55, 2.84)
CHISEL [93]	101	Stage I/II, inoperable or refusing surgery	3D	SBRT 54 Gy/3 fx 48 Gy/4 fx 66 Gy/33 fx, or 50 Gy/20 fx	Time to local treatment failure	2.1 years	Local progression: 14% SABR vs. 31% standard radiotherapy; SABR had improved FFF (HR 0.32, p = 0.0077)
RTOG 0915 [105,106]	94	Stage I/II peripheral inoperable	IMRT 4D CT allowed	34 Gy/1 fraction 48 Gy/4 fx	Rate of grade 3 or higher	4 years	Toxicity rates (Grade 3+): 34 Gy (Arm 1): 2.6% 48 Gy (Arm 2): 11.1% Primary tumor failure: 34 Gy: 10.6% (CI: 3.3–23.1%) vs. 48 Gy: 6.8% (CI: 1.7–16.9%) OS: 34 Gy: 29.6% (CI: 16.2–44.4%) vs. 48 Gy: 41.1% (CI: 26.6–55.1%)

Legend: TRTM: treatment-related mortality; FFF: freedom from failure.