Table 2.

Analyzing the relationship between PIV and oncological outcomes using multivariable logistic regression.

		Lymph Node			Advanced Tumor Grading			Locoregionally Extended State
Characteristic	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
PIV (Reference: low)
High	1.84	0.76, 4.47	0.17	2.87	1.36, 6.04	0.005	3.30	1.60, 6.77	0.001
Age	1.14	0.33, 3.88	0.82	0.75	0.28, 1.99	0.576	1.00	0.39, 2.57	0.98
Smoke (Reference: no)
Smoke	0.59	0.23, 1.50	0.27	0.93	0.37, 2.33	0.890	1.48	0.59, 3.70	0.39
Sex (Reference: male)
Female	0.56	0.19, 1.60	0.28	0.31	0.10, 0.90	0.032	0.53	0.20, 1.42	0.21
Clinical tumor stage
(Reference: cTa/cTis/cT1)
cT2	4.92	1.84, 13.13	0.001	45.10	9.46, 215.03	<0.001	29.15	6.32, 134.36	<0.001
cT3/cT4	11.16	3.86, 32.27	<0.001	23.49	4.91, 112.20	<0.001
Goodness-of-fit test	Hosmer–Lemeshow test		0.20			0.68			0.91
AUC
Model with PIV		AUC: 0.78			AUC: 0.80			AUC: 0.81
Model without PIV		AUC: 0.76 (+2%)			AUC: 0.77 (+3%)			AUC: 0.76 (+5%)
(p = difference model)			0.27			0.12			0.04

PIV = Pan-immune inflammation value; OR = Odds Ratio; CI = Confidence Inter al; AUC = Area under the curve.