Table 3.

Analyzing the relationship between NLR and oncological outcomes using multivariable logistic regression.

		Lymph Node			Advanced Tumor Grading			Locoregionally Extended State
Characteristic	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
NLR (Reference: low)
High	1.47	0.65, 3.36	0.35	1.98	0.97, 4.05	0.06	1.60	0.80, 3.18	0.17
Age	1.13	0.33, 3.82	0.84	0.76	0.29, 1.99	0.588	1.01	0.40, 2.51	0.97
Smoke (Reference: no)
Smoke	0.54	0.21, 1.35	0.19	0.79	0.32, 1.94	0.620	1.22	0.51, 2.93	0.65
Sex (Reference: male)
Female	0.58	0.20, 1.66	0.31	0.31	0.11, 0.92	0.035	0.57	0.21, 1.48	0.25
Clinical tumor stage
(Reference: cTa/cTis/cT1)
cT2	4.99	1.88, 13.25	0.001	44.10	9.29, 209.21	<0.001	27.01	5.97, 122.05	<0.001
cT3/cT4	13.19	4.72, 36.85	<0.001	32.22	6.73, 154.29	<0.001
Goodness-of-fit test	Hosmer–Lemeshow test		0.97			0.25			0.91
AUC
Model with NLR		AUC: 0.77			AUC: 0.78			AUC: 0.77
Model without NLR		AUC: 0.76 (+1%)			AUC: 0.77 (+1%)			AUC: 0.76 (+1%)
(p = difference model)			0.51			0.55			0.55

NLR = Neutrophil to lymphocyte ratio; OR = Odds ratio; CI = Confidence interval; AUC = Area under the curve.